EXPLORE G2D2’S COLLABORATIVE APPROACH

Click on any discipline to see what goes into it and how it all comes together.


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DATA SCIENCES

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DISCOVERY
SCIENCES

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PRECISION CHEMISTRY

 

Data Sciences

DISCOVERY Sciences

PRECISION CHEMISTRY

IMMUNODEMENTIA

A novel, genetically validated target modulating immune mechanisms to treat dementia.

CHOOSE THE RIGHT TARGET

Finding a disease risk-associated gene is just the first step in the drug development journey. We begin by understanding the connection between a risk or a protection-associated genetic variant and the underlying biology of disease.

The Immunodementia Biology group works closely with colleagues in Data Sciences to dissect risk variant effects on protein and cell functions, and to establish disease-relevant assays that reflect target activity. Working internally and with collaborators, we’re always trying to expand the biology around our targets.

ADVANCE FROM MECHANISM TO THERAPY

We apply an array of technologies to find and optimize molecules that will turn disease processes towards a more-healthy function. Following through, we analyze the effects of our candidate drugs in relevant in-vitro, in-vivo and ex-vivo systems, and explore molecular markers that will help us choose appropriate patient populations and assess drug effects in clinic. Unbiased ’omics’ approaches give us a comprehensive view of disease mechanisms and compound effects, while cutting-edge optical imaging provides critical mechanistic insights.